On December 20, 2016, the U.S. Environmental Protection Agency (EPA)announced the start of a pilot program to evaluate the usefulness and acceptability of a mathematical tool (the GHS Mixtures Equation), which is used in the Globally Harmonized System of Classification and Labeling of Chemicals (GHS). EPA states that the goal of the pilot program is to “evaluate the utility and acceptability of the GHS Mixtures Equation as an alternative to animal oral and inhalation toxicity studies for pesticide formulations.”
PETA UK and PETA Netherlands staff attended a meeting in Hague last week at which Dutch Secretary of State for Economic Affairs Martijn van Dam announced his intention for the Netherlands to end the use of animals in safety tests for chemicals, food ingredients, pesticides, veterinary medicines, and vaccines by 2025. This means that mice, rats, rabbits, and other animals will no longer have these substances forced down their throats or injected into their bodies, causing sickness, convulsions, diarrhoea, haemorrhaging, and worse before they are killed – a move that can save countless animals.
PETA is accepting proposals to award a VITROCELL® exposure system—valued at up to $100,000—to researchers who will use it to avoid testing on animals. The VITROCELL exposure system can be used to deliver aerosolized test substances to human lung cells to predict human health effects more accurately than tests on animals. DEADLINE: March 30, 2017. The PETA International Science Consortium is also purchasing similar equipment for IIVS in support of our efforts to replace animals in inhalation testing. Read more.
IIVS' work with the China Food and Drug Administration (CFDA) and its subsidiary body, the National Institute for Food and Drug Control (NIFDC) has paid off with the recent approval of the T3 Neutral Red Uptake Phototoxicity Test, the first non-animal test method that can be used for safety tests in cosmetics sold in China. This article references IIVS's work with the CFDA and NIFDC over the last several years to provide training and education around non-animal methods for safety assessments in conjunction with China's ongoing efforts to modernize their testing requirements and reduce their reliance on animals.
Taiwan has passed a bill to ban cosmetics testing on animals. With a three-year implementation period in place, it will take effect from October 2019.
An adverse outcome pathway, or AOP, is a highly structured way of describing a toxicological process which can lead to an adverse health effect in humans or wildlife, caused by an unsafe exposure to a chemical substance. The first five adverse outcome pathways have now been published by experts. The AOPs are novel knowledge management tools in toxicology and are useful for supporting risk assessment to human health. They are also valuable for helping to avoid animal testing through the use of alternative methods.