Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS | Industries Pharmaceutical
61
archive,paged,tax-industry,term-pharmaceutical,term-61,paged-2,ajax_fade,page_not_loaded,,qode_grid_1300,footer_responsive_adv,hide_top_bar_on_mobile_header,qode-content-sidebar-responsive,qode-child-theme-ver-,qode-theme-ver-17.2,qode-theme-bridge,disabled_footer_bottom,qode_header_in_grid,wpb-js-composer js-comp-ver-5.6,vc_responsive

Archive

IIVS at SOT 2018

February 8, 2018
IIVS will have several events and posters at the upcoming SOT meeting, March 11-15, in San Antonio, TX.  The events and three of our five posters focus on our respiratory toxicology program in support of our new laboratory that opened in 2017.  Other posters examine topics in phototoxicity.  Be sure to visit our booth at the meeting - Booth #533.   View more details on our events and posters at SOT....

Reducing the Use of Animals in Safety Testing: Strategic Roadmap Released

February 1, 2018
The National Toxicology Program, in collaboration with other US federal agencies, has published a strategic roadmap offering a new framework for the safety testing of drugs & chemicals aimed at reducing the use of animals. Read more....

Video: Bovine Corneal Opacity & Permeability Test – Spanish

October 16, 2017
This 13- minute training video demonstrates how to perform the BCOP assay according to the Test Guidelines set forth for the assay by the Organization for Economic Co-operation and Development (OECD TG 437). The video focuses on steps that are critical to the success of the assay such as handling of the isolated cornea and removal of the test material from the cornea at the conclusion of the exposure time. ...

Video: The 3T3 Neutral Red Uptake Phototoxicity Test – Spanish

October 6, 2017
This new training video explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to video production...

Quality Considerations: Redefining Test Systems from Animals to Tissues and Beyond

August 28, 2017
The use of non-whole animal test methods transforms the way regulatory requirements are applied in preclinical testing. Recent global regulatory initiatives emphasize the importance of transitioning to human relevant assays and test systems that do not use animals. When these methods are moved from research into the regulated arena, GLP principles must be followed. The GLPs were originally written in the 1970s, when the vast majority of regulated research was performed using animals as the test system. Current innovative, alternative...

Multiparametric Image Analysis of Rat Dorsal Root Ganglion Cultures to Evaluate Peripheral Neuropathy-Inducing Chemotherapeutics

March 30, 2017
Chemotherapy-induced peripheral neuropathy (CIPN) is a major, dose-limiting adverse effect experienced by cancer patients. Advancements in mechanism-based risk mitigation and effective treatments for CIPN can be aided by suitable in vitro assays.  To this end, we developed a multiparametric morphology-centered rat dorsal root ganglion (DRG) assay. Read article....

Video: The 3T3 Neutral Red Uptake Phototoxicity Test — Chinese

November 21, 2016
This training video with Chinese subtitles explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UVA/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to...

Video: The 3T3 Neutral Red Uptake Phototoxicity Test — Portuguese

November 21, 2016
This new training video with Portuguese subtitles explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques....

Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology

October 18, 2016
This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides...

NociOcular Eye Sting

August 24, 2016
Many personal care and cosmetic products accidentally contact the eye, which is very sensitive to numerous compounds that would otherwise be benign when applied to the skin.  Due to the pain and stinging that is perceived, it is important for manufacturers of these products to be aware of the potential pain perceived should eye contact occur. Due to the subjective nature of the unpleasant perception, animal models are inconclusive and may even be prohibited due regulations.  Fortunately, IIVS has developed a...