March 18, 2019
Next generation tobacco and nicotine products (NGPs) such as electronic cigarettes (EC) and tobacco heating products (THP) have reduced toxicity and hold great potential for reducing the risks associated with cigarette smoking. NGPs may also have hygiene benefits for consumers that switch to these products. In this study, the level of skin staining was assessed following exposure to a scientific reference cigarette (3R4F) and NGPs across the risk continuum; a prototype EC or a commercial THP (glo™).
Test articles (TAs) were...
Tobacco | Annette Dalrymple | British American Tobacco | Devin Sheehan | e-cigarette | Holger Behrsing | next generation product | NGP | Sarah Corke | skin staining
March 28, 2018
Robust non-animal models and assays for pulmonary toxicology are required to make competent product development and risk assessments for new materials requiring toxicity testing. Three in vitro assays (goblet cell hyperplasia [GCH], ciliary beat frequency [CBF], and MUC5AC quantitation) were evaluated for performance and reproducibility. To assess these assays, 6 laboratories contributed data using a common protocol utilizing IL-13 as an inducer of adverse mucociliary-relevant tissue changes. MatTek EpiAirway™ and Epithelix MucilAir™ 3D tissue models were used to evaluate endpoints...
Bronchial/Tracheal | Ciliary Beat Frequency | Goblet Cell Hyperplasia | Mucin Production | Tobacco | A. Maione | B. Keyser | D. Azzopardi | e-cigarette | H. Behrsing