Our very own Holger Behrsing, PhD, will be presenting at SIVB's Annual Meeting in St. Louis. His presentation on Tuesday, June 5th is titled "Pragmatic Use of State-of-the-Art Lung Models to Evaluate Exposure-induced, Adverse Pulmonary Effects" and will provide an overview of in vitro/ex vivo...
Registration is now open for the 7th Annual ASCCT Meeting - Predictive Toxicology: Strategies for Implementing New Approaches - being held September 11-12, 2018, at the National Institutes of Health in Bethesda, MD. Learn More...
The non-binding resolution calls for a diplomatic push towards a global animal testing ban for cosmetics to be in place by 2023. Europe fully banned cosmetic animal testing in 2013, but it is still permitted in 80% of countries worldwide. Read article....
The Humane Society of the United States thanks Governor Ralph Northam for signing a bill to reduce the use of animals in product testing. Virginia is only the fourth state in the country to pass such a law. Delegate Jennifer Boysko, D-86, was the lead...
The EPA has released a new policy that will allow chemical and pesticide makers to provide the EPA with data from non-animal test methods when assessing for skin allergies. Congratulations to the EPA OPP team for working so hard to put in place this new...
IIVS, in collaboration with Philip Morris International, recently presented data highlighting the predictive capability of in vitro assays in determining human response to non-burn tobacco products. Moreover, a ring trial of 6 independent laboratories has generated evidence that key events involved in human disease caused...
To address ocular device induced phototoxicity, an in vitro 3T3 Neutral Red Uptake Phototoxicity test (OECD 432) for chemicals has been modified. Soft contact lenses formulated with three different photo-absorbing compounds and chemical solutions of these compounds were evaluated....
Alternative methods, including the validated 3T3 Neutral Red Uptake (NRU) Phototoxicity assay (OECD TG 432) may be used as a pre-clinical test to address phototoxicity. Currently, there are no validated alternative test methods to identify photoallergens; however, there are several validated alternative test methods to...
Robust non-animal models and assays for pulmonary toxicology are required to make competent product development and risk assessments for new materials requiring toxicity testing. Three in vitro assays (goblet cell hyperplasia [GCH], ciliary beat frequency [CBF], and MUC5AC quantitation) were evaluated for performance and reproducibility....
E-vapor product liquids contain a variety of ingredient combinations that should be assessed for human risk. One human lung-relevant testing platform with reasonable throughput, is human precision-cut lung slices (HuPCLS). HuPCLS are arguably the most complex non-animal model of the lung, retaining native architecture and...