The use of in vitro new approach methodologies (NAMs) to assess respiratory irritation depends on several factors, including the speci cs of exposure methods and cell/tissue-based test systems. This topic was examined in the context of human health risk assessment for cleaning products at a...
This work evaluated a non-animal toolbox to be used within a next-generation risk assessment (NGRA) framework to assess chemical-induced lung effects using human upper and lower respiratory tract models, namely MucilAir -HF and EpiAlveolar systems, respectively....
Allergic contact dermatitis (ACD) is an immunologic reaction to a dermal chemical ex-posure that, once triggered in an individual, will result in an allergic response following subsequent encounters with the allergen. Air Force epidemiological consultations have in-dicated that aircraft structural maintenance workers may experience ACD...
Gaithersburg, Md.— This week, five scientists from India will attend a globally recognized, non-animal toxicology training course in the United States as a result of a partnership between PETA Science Consortium International e.V., Colgate Palmolive, and the Institute for In Vitro Sciences (IIVS). IIVS will...
To address a lack of suitable non-animal tools to screen novel ingredients in personal care products for mutagenic/clastogenic activity after solar light exposure, we initiated a three-phase program to develop a new approach methodology (NAM) which integrates established UVA/UVB/visible light (UV/vis) photo-activation techniques to the...
As new approach methodologies (NAMs) are increasingly explored to identify dependable and accurate non-animal alternatives to predict human toxicities, several 3-dimensional test systems have emerged as excellent models of the human respiratory tract. Among these, human precision-cut lung slices (hPCLS) are considered highly relevant, containing...
The ToxTracker® assay has gained attention as a second tier non-animal test method to the standard battery of in vitro genotoxicity assays by providing mechanistic insights into the modes of action including DNA damage, oxidative stress, cellular stress, protein damage, and the validated method is...
Photoreactivity evaluation is one of the initial screenings in a photosafety assessment that can identify compounds which may have the potential to produce various types of adverse photo reactions, including photoirritation (or phototoxicity), photoallergy, and photogenotoxicity. The Reactive Oxygen Species (ROS) Photoreactivity Assay, adopted under...
IIVS is excited to announce the successful transfer of the Reactive Oxygen Species (ROS) photoreactivity assay into our laboratory. This high-throughput, in chemico screening assay, adopted as OECD Test Guideline 495, is designed to assess photoreactivity potential of test substances through measurement of two ROS:...