Featured Post
Use of alternative test methods in a tiered testing approach to address photoirritation potential of fragrance materials
January 3, 2022Happy New Year! IIVS is pleased to greet 2022 with the announcement of a joint publication with the Research Institute for Fragrance Materials (RIFM) involving the evaluation of photoirritation potential of over 100 compounds. This effort, spanning the course of 7 years, involved a tiered testing approach with the application of 3 OECD test guidelines: TG 101, 432 and the recently accepted 498, which codifies the acceptance of Reconstructed human Epidermis as a model for assessing this endpoint. Read the full...
IIVS e-News – December 2021
December 9, 2021In addition to IIVS’ non-animal safety testing services, we also provide efficacy testing designed to evaluate raw materials and formulations for anti-inflammatory and skin tone modulating properties. Inflammation is a common effect experienced after encounters with irritating substances, bacterial infection or by those suffering from auto-immune diseases....
IIVS e-News – September 2021
September 16, 2021It’s been a very exciting year in the field of New Approach Methodologies (NAMs) with the release of the OECD 497 and 498 Test Guidelines which have codified Defined Approaches for Skin Sensitization and the Reconstructed Human Epidermis Phototoxicity Test, respectively....
IIVS Posters and Presentations at the 11th of the World Congress on Alternatives and Animal Use in the Life Sciences – Check out our activities!
August 17, 2021...
Participation at the 2021 Annual Meeting of the American Society for Cellular and Computational Toxicology is Complimentary This Year!
August 2, 2021As we are once again meeting online, we are pleased to announce that access to the 2021 meeting will be FREE for all attendees. However, if you are interested in helping further ASCCT’s activities, please consider becoming a member—one-year memberships for students are only $20 USD, and individual memberships are $50 USD. By joining as a member, you will have early-bird access to register for our monthly webinars, as well as receive exclusive industry-specific job postings and other relevant opportunities shared...
IIVS e-News – July 2021
June 30, 2021The Defined Approaches (DAs) to Skin Sensitization Test Guideline cites 2 strategies which can be used to evaluate hazard potential of compounds and 1 strategy to evaluate GHS potency. The hazard DAs involve in vitroapproaches to the evaluation of sensitization using multiple assays which evaluate different steps in the Adverse Outcome Pathway. Both the "2 out of 3" (Fig 1) and "Key Event 3/1" approaches (Fig 2) have been included in the OECD Test Guideline. The potency assessment is an...
IIVS e-News – May 2021
May 6, 2021IIVS and the Research Institute for Fragrance Materials (RIFM) have initiated a collaboration to develop tests designed to assess potential respiratory allergens. Developing a reliable, in vitroassay to assess the allergenicity of materials to the airway tract has been an area of active research for well over a decade, however most efforts have resulted in poor accuracy and the inability to distinguish airway sensitizers from irritants. By combining the extensive expertise and knowledge base in the field of respiratory toxicology...
How a GIVIMP Certification Program Can Increase Confidence in In Vitro Methods
April 20, 2021Regulatory bodies, validation authorities, method developers, and industry toxicologists realize the need to increase confidence in the scientific validity of novel in vitro methods – especially those being proposed for regulatory application ....
IIVS Co-Publishes Article on Ocular Animal Model Alternatives
April 20, 2021The human eye may be exposed to chemicals through various situations, such as accidental splashing or exposure to chemical particles, vapours or gases. Workers and consumers are usually advised to immediately wash eyes generously with water following exposure....
IIVS to collaborate with RIFM to develop non-animal technologies for respiratory allergy
March 31, 2021The Institute for In Vitro Sciences (IIVS) and the Research Institute for Fragrance Materials (RIFM) announce a collaboration to develop a non-animal (in vitro) test designed to assess potential respiratory allergens....