Archive

Human In Vitro Models for Respiratory Toxicology: Evaluation of Goblet Cell Hyperplasia, Mucus Production, and Ciliary Beating Assays

March 28, 2018
Robust non-animal models and assays for pulmonary toxicology are required to make competent product development and risk assessments for new materials requiring toxicity testing. Three in vitro assays (goblet cell hyperplasia [GCH], ciliary beat frequency [CBF], and MUC5AC quantitation) were evaluated for performance and reproducibility. To assess these assays, 6 laboratories contributed data using a common protocol utilizing IL-13 as an inducer of adverse mucociliary-relevant tissue changes. MatTek EpiAirway™ and Epithelix MucilAir™ 3D tissue models were used to evaluate endpoints... Bronchial/Tracheal | Ciliary Beat Frequency | Goblet Cell Hyperplasia | Mucin Production | Tobacco | A. Maione | B. Keyser | D. Azzopardi | e-cigarette | H. Behrsing

Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology

October 18, 2016
This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides... 3T3 Neutral Red Uptake | Acute Respiratory Toxicity | Assessing Corneal Recovery | BCOP | Bronchial/Tracheal | CAMVA | Chronic Respiratory Toxicity | Ciliary Beat Frequency | Corneal Recovery Modeling | Corrositex

Next Generation Tobacco Products

August 24, 2016
IIVS has a long-standing history of working with various industries to help establish or utilize in vitro models for the prediction of risk and the assessment of products under development. With the Food and Drug Administration extending its authority to all tobacco products (including e-cigarettes, cigars, and hookah) the tobacco industry is faced with the task of assessing product safety for product development and regulatory submission. Further, the manufacture of tobacco products may entail risk to workers that come in... 3T3 Neutral Red Uptake | Acute Respiratory Toxicity | Bronchial/Tracheal | Chronic Respiratory Toxicity | Ciliary Beat Frequency | DPRA | Eye Irritation Test | Goblet Cell Hyperplasia | Inflammatory Biomarker Profiling | Inflammatory Cytokine Expression

Digital Dispensing onto 3D Airway Tissue: Delivery of Patterned, Picoliter Volumes for Direct Apical Surface Coverage with Precise Quantities of Test Material

April 4, 2016
Source: In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacc…... Acute Respiratory Toxicity | Bronchial/Tracheal | Household & Consumer Products | Tobacco

Effect of Acclimation Conditions on 3D Human in vitro ALI Airway Models: Exposure-induced Inflammatory Response and Sampling Location-specific Results

March 15, 2016
Source: SOT 2016... Acute Respiratory Toxicity | Bronchial/Tracheal | Household & Consumer Products | Tobacco

2014 CORESTA: Toxic Insult to Rat Precision Cut Lung Slices

March 10, 2016
Source: CORESTA 2014... Bronchial/Tracheal | Precision Cut Lung Slices (PCLS) | Pulmonary Models | Household & Consumer Products | Tobacco

2014 TSRC Lung Slices for COPD

March 10, 2016
Source: TRSC 2014... Bronchial/Tracheal | Chronic Respiratory Toxicity | Tobacco

Overview: Etiology of COPD and In Vitro Models

March 10, 2016
... Bronchial/Tracheal | Chronic Respiratory Toxicity | Tobacco

Detection of Inflammation and Parenchymal Damage Using Precision-cut Lung Slices

March 10, 2016
... Bronchial/Tracheal | Precision Cut Lung Slices (PCLS) | Pulmonary Models | Household & Consumer Products | Tobacco

3D Reconstructed Human Airway Models: Effect of Acclimation Conditions on Biomarker and Inflammatory Response Following Tissue Challenge

March 10, 2016
Source: TRSC 2015... Acute Respiratory Toxicity | Bronchial/Tracheal | Tobacco