March 2015
Protocol Considerations for Testing Surfactants and Surfactant-based Formulations in the Bovine Corneal Opacity and Permeability Assay
March 23, 2015The Bovine Corneal Opacity and Permeability (BCOP) assay is an ex vivo test for predicting ocular irritation. For regulatory classification, OECD Test Guideline (TG) 437 specifies that liquid and solid surfactants may be tested as 10% aqueous dilutions for 10 minutes, although alternate dilutions and exposure times may be conducted with scientific rationale. Without question, surfactant solids should not be tested using the solid chemical protocol, since overexposure conditions are likely. In the absence of clear guidance from these regulatory...
A TIERED IN VITRO IRRITATION/CORROSION TESTING STRATEGY FOR GHS CLASSIFICATION OF PHARMACEUTICAL COMPOUNDS
March 23, 2015Source: 2015 Society of Toxicology Meeting...
Evaluation of TRPV1 Activity to Assess the Eye Stinging Potential of Cosmetic Formulations
March 23, 2015Source: 2015 Society of Toxicology Meeting...
Using the Novel NociOcular Assay to Predict the Eye Sting Potential of Shampoos and Sunscreen Products
March 23, 2015Source: 2015 Society of Toxicology Meeting...