Author: Jane Ryan
Observations on the Use of the Bovine Corneal Opacity and Permeability (BCOP) Assay to Evaluate the Eye Irritation Potential of Prototype Cosmetic Formulations Containing Salicylic Acid, Glycolic Acid and Ethanol
August 24, 2014Source: World Congress 9...
Webinar: Reconstructed Human Skin Micronucleus Assay (RSMN): A Novel Micronucleus Assay in a 3D Human Skin Model
July 31, 2014...
China FDA Signs MOU with US Laboratory to Promote Non-Animal Testing Methods in China
June 17, 2014GAITHERSBURG, MARYLAND – The Institute for In Vitro Sciences (IIVS) last week signed a Memorandum of Understanding with the National Institute for Food and Drug Control (NIFDC), a subordinate agency of the China Food and Drug Administration (CFDA). The two organizations will work collaboratively on a number of projects focused on cosmetic safety testing designed to promote in vitro (non-animal) techniques in China. In November 2013, IIVS held a week long training workshop at the NIFDC laboratory in Beijing to teach...
TIERED TESTING STRATEGY USING VALIDATED IN VITRO ASSAYS FOR THE ASSESSMENT OF SKIN AND EYE CORROSION/IRRITATION OF PHARMACEUTICAL INTERMEDIATES
March 25, 2014Source: SOT 2014...
Testing Framework for Prediction of Ocular Irritation Using the Bovine Corneal Opacity and Permeability (BCOP) Assay and Chorioallantoic Membrane Vascular Assay (CAMVA)
March 25, 2014Source: SOT 2014...
Investigations on Reducing Ocular Irritation Associated with Harsh Ingredients by Altering Physicochemical Properties of the Formulation
March 25, 2014Source: SOT 2014...
IN VITRO SAFETY PROFILE OF PERSONAL CARE PRODUCTS – USE OF AN IN VITRO TESTING PLATFORM BASED ON A RECONSTRUCTED VAGINAL TISSUE MODEL
March 25, 2014Source: SOT 2014...
Webinar Slides: The NociOcular Assay: A Novel Assay Looking at TRPV1 Channel Activity for Eye Sting Predictions Webinar
March 14, 2014...
Validation and Application of the KeratinoSens Assay, a Novel In Vitro Skin Sensitization Assay
January 1, 2014...
Predicting Ocular Irritation of Surfactants Using the Bovine Corneal Opacity and Permeability Assay
January 1, 2014The Bovine Corneal Opacity and Permeability (BCOP) assay is an ex vivo test used to evaluate ocular irritation. According to the OECD Test Guideline (TG) 437, the BCOP assay can be used to identify chemicals which induce severe/corrosive eye irritation and those that do not require classification. However, BCOP has historically under-predicted certain anionic surfactants, when tested according to the standard liquid protocol. Since neither the basis for selecting the appropriate surfactant test methods, nor the justification for modifications are...