Archive
Webinar: Skin Tone Modulation: In Vitro Pre-clinical and Clinical Efficacy Testing Strategies and Innovative Solutions in Cosmetics
July 13, 2017Addressing uneven skin tone often associated with photo-aging is a key area of interest in the cosmetic industry. The design of novel, safe, and efficacious actives and ingredients capable of inducing subtle changes in skin tone can be accomplished using modern, relevant and reliable pre-clinical testing strategies prior to clinical assessment. During this one-hour webinar, IIVS Study Director, Dr. Gertrude-Emilia Costin and Dr. Manpreet Randhawa, Principal Scientist at Johnson & Johnson, discuss optimized in vitro testing platforms using pigmented tissue models...
View Our Webinar on Skin Tone Modulation
June 30, 2017View the recording and slides from our webinar on skin tone modulation that was held on Thurs., June 29. The one-hour webinar features IIVS study director, Dr. Gertrude-Emilia Costin, and Johnson & Johnson principal scientist, Dr. Manpreet Randhawa as they discuss optimized in vitro testing platforms using pigmented tissue models that assess the capacity of ingredients and formulations that impact skin tone. ...
Navigating the Claim Substantiation Maze in Cosmetics Industry
June 15, 2017Read this article by IIVS study director Dr. Gertrude-Emilia Costin and biologist Asha Shravanthi Pidathala in the June 2017 issue of Eurocosmetics. The article examines modern, relevant, and reliable in vitro testing strategies using pigmented tissue models that assess the capacity of ingredients and formulations that impact skin tone. ...
In Vitro Assessment of Skin Irritation Potential of Surfactant-based Formulations by Using a 3-D Skin Reconstructed Tissue Model and Cytokine Response
January 24, 2017The personal care industry is focused on developing safe, more efficacious, and increasingly milder products, that are routinely undergoing preclinical and clinical testing before becoming available for consumer use on skin. In vitro systems based on skin reconstructed equivalents are now established for the preclinical assessment of product irritation potential and as alternative testing methods to the classic Draize rabbit skin irritation test. We have used the 3-D EpiDerm™ model system to evaluate tissue viability and primary cytokine interleukin-1α release...
Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology
October 18, 2016This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides...
Pigmentation & Melanogenesis
August 23, 2016The efficacy of ingredients or final formulations in modulating human skin pigmentation can be assessed in vitro by analysis of melanin production in reconstructed tissue models of various phototypes. In addition, this testing platform is suitable for investigation of the dermal irritation potential of test materials after repeated exposures using a tissue viability endpoint. The evaluation of the potential impact on melanin production of raw ingredients or finished products intended for the modulation of skin pigmentation can be assessed using pigmented...
Occupational Safety & Industrial Hygiene
July 28, 2016Employers are required to inform workers of the hazards of the chemicals or products that they are using. Many in vitro assays are suited to accomplish this goal. As Hazard Communication is now aligned with the Globally Harmonized System (GHS), assays that are approved for assigning GHS hazard categories can provide a method for properly labelling chemicals and preparing safety data sheets. Skin Corrosion assays (Reconstructed Human Epidermis (OECD TG 431) and Membrane Barrier Test (OECD TG 435)) can be used...