March 30, 2017Regulatory restrictions on animal use have increased the reliance of risk assessors and regulators on in vitro test systems. Ideally, tissue-based assays could replace the animal studies as follow-up tools to verify results from standard in vitro assays. The RSMN assay combines the EpiDerm™ 3D reconstructed skin (RS) model with the micronucleus (MN) assay to provide a more realistic model for evaluating the genotoxic potential of dermally applied chemicals or products, such as cosmetics....
Dermal | Reconstructed Skin Micronucleus (RSMN)
August 24, 2016Reconstructed Skin Micronucleus (RSMN) Using the EpiDerm™ Reconstructed Human Epidermis Model
RSMN is used to evaluate the genotoxicity potential of the test article to the EpiDerm™ Skin Model. Genotoxicity potential is determined by assessing whether the micronucleus frequency in tissues exposed to the test article showed a statistically significant increase relative to the tissues exposed to the solvent (negative) control.
Evaluate the genotoxic potential of new ingredients and chemicals at exposure-relevant doses
RSMN determines the skin genotoxicity/mutagenicity potential of a test substance...
Reconstructed Skin Micronucleus (RSMN)
August 24, 2016Specialty chemicals are chemical products identified on the basis of their performance or function, rather than their composition. They can be single-chemical entities or formulations and cover a wide range of product categories such as consumer products, cosmetics, food additives, manufacturing, etc.
As a result, testing for these chemicals can include a wide range in the irritation spectrum, from materials that are classified as mild irritants to those that are designated as corrosive. The testing needs also cover a wide range...
Reconstructed Skin Micronucleus (RSMN) | Skin Irritation Test | Cleaning Products