Archive

Webinar: In Vitro 3T3 Phototoxicity Assay Practical Experiences Assay Optimization and Challenges

Protocol Considerations for Testing Surfactants and Surfactant-based Formulations in the Bovine Corneal Opacity and Permeability Assay

March 23, 2015
The Bovine Corneal Opacity and Permeability (BCOP) assay is an ex vivo test for predicting ocular irritation. For regulatory classification, OECD Test Guideline (TG) 437 specifies that liquid and solid surfactants may be tested as 10% aqueous dilutions for 10 minutes, although alternate dilutions and exposure times may be conducted with scientific rationale. Without question, surfactant solids should not be tested using the solid chemical protocol, since overexposure conditions are likely. In the absence of clear guidance from these regulatory... BCOP | Cosmetic & Personal Care | Household & Consumer Products | Specialty Chemical

RSMN (Reconstructed Skin Micronucleus Assay): Update on the ongoing validation

August 24, 2014
Source: World Congress 9... Reconstructed Skin Micronucleus (RSMN) | Cosmetic & Personal Care | Specialty Chemical

Webinar: Reconstructed Human Skin Micronucleus Assay (RSMN): A Novel Micronucleus Assay in a 3D Human Skin Model

July 31, 2014
... Reconstructed Skin Micronucleus (RSMN) | Cosmetic & Personal Care | Specialty Chemical

Predicting Ocular Irritation of Surfactants Using the Bovine Corneal Opacity and Permeability Assay

January 1, 2014
The Bovine Corneal Opacity and Permeability (BCOP) assay is an ex vivo test used to evaluate ocular irritation. According to the OECD Test Guideline (TG) 437, the BCOP assay can be used to identify chemicals which induce severe/corrosive eye irritation and those that do not require classification. However, BCOP has historically under-predicted certain anionic surfactants, when tested according to the standard liquid protocol. Since neither the basis for selecting the appropriate surfactant test methods, nor the justification for modifications are... BCOP | Cleaning Products | Specialty Chemical

Validation and Application of the KeratinoSens Assay, a Novel In Vitro Skin Sensitization Assay

December 1, 2013
Source: JSAAE meeting... Fragrance & Flavors | Specialty Chemical | Assay Validation

Webinar: Integrated Testing Strategies for In Vitro Skin Sensitization Testing

Webinar: In Vitro Phototoxicity Assays

Webinar: Short Time Exposure (STE) Assay: Method and Use

March 19, 2013
... Short Time Exposure | Cosmetic & Personal Care | Specialty Chemical

CHOOSING THE APPROPRIATE SOLVENT FOR SOLID MATERIALS TESTED IN THE BOVINE CORNEAL OPACITY AND PERMEABILITY (BCOP) IN VITRO ASSAY

March 12, 2013
Source: Presented at the 2013 Society of Toxicology Annual Meeting... BCOP | Corneal Recovery Modeling | Specialty Chemical