Posters & Presentations
3D Reconstructed Human Airway Models: Effect of Acclimation Conditions on Biomarker and Inflammatory Response Following Tissue Challenge
March 10, 2016Source: TRSC 2015
Cytokine induction in the 3D EpiDerm™ skin model used as an in vitro preclinical screening tool for formulations with anti-inflammatory action
October 1, 2015Source: ASCCT 2015
Protocol Considerations for Testing Surfactants and Surfactant-based Formulations in the Bovine Corneal Opacity and Permeability Assay
March 23, 2015The Bovine Corneal Opacity and Permeability (BCOP) assay is an ex vivo test for predicting ocular irritation. For regulatory classification, OECD Test Guideline (TG) 437 specifies that liquid and solid surfactants may be tested as 10% aqueous dilutions for 10 minutes, although alternate dilutions and exposure times may be conducted with scientific rationale. Without question, surfactant solids should not be tested using the solid chemical protocol, since overexposure conditions are likely. In the absence of clear guidance from these regulatory documents, we present on the testing of a few common surfactant ingredients (sodium lauryl sulfate, Triton X-100, and benzalkonium chloride), and surfactant-based liquid and solid formulations in BCOP using standard and modified dilutions and exposures to evaluate the impact of these variables.
A TIERED IN VITRO IRRITATION/CORROSION TESTING STRATEGY FOR GHS CLASSIFICATION OF PHARMACEUTICAL COMPOUNDS
March 23, 2015Source: 2015 Society of Toxicology Meeting
Evaluation of TRPV1 Activity to Assess the Eye Stinging Potential of Cosmetic Formulations
March 23, 2015Source: 2015 Society of Toxicology Meeting
Using the Novel NociOcular Assay to Predict the Eye Sting Potential of Shampoos and Sunscreen Products
March 23, 2015Source: 2015 Society of Toxicology Meeting
Evaluation of a Reconstructed Human Oral Buccal Tissue Model as a Testing Platform for Determining the Oral Irritation Potential of Tobacco Products
December 1, 2014Source: Assessment of In Vitro COPD Models for Tobacco Regulatory Science
Toxic Insult to Rat Precision Cut Lung Slices Increases Tissue Cytokine Levels and Activation of Macrophages, and Causes Acute Damage, While Prolonged Insult May Lead to Increased Deposition of Collagen – a Marker of Fibrosis
December 1, 2014Source: Assessment of In Vitro COPD Models for Tobacco Regulatory Science
Assessing increased sensitivity and variability issues in an established in vitro phototoxicity testing program
November 1, 2014Source: 2014 ASCCT Meeting