animal alternatives Tag
PETA Science Group and Tobacco Companies Donate to Save Animals
August 28, 2019Donated Equipment Will Help to Replace Animals in Respiratory Toxicity Testing Gaithersburg, MD — The PETA International Science Consortium Ltd., Imperial Brands PLC, Altria Client Services (ALCS), British American Tobacco PLC, and Philip Morris International Inc have joined together to donate equipment that can help to replace the use of animals in respiratory testing with more human-relevant, non-animal test methods. The equipment — worth $110,000 and manufactured by Germany-based VITROCELL Systems — was donated to the Institute for In Vitro Sciences (IIVS),...
IIVS and Partners Win Contract from the European Commission to Develop Training for Non-animal Testing Methods
July 16, 2019July 16, 2019, Gaithersburg, MD – The Institute for In Vitro Sciences (IIVS) is pleased to announce it is part of a winning consortium, headed by SYRCLE (the Systematic Review Centre for Laboratory animal Experimentation), to develop interactive eLearning training modules. The application of the Replacement, Reduction and Refinement of animal testing, commonly known as “The 3Rs,” is a requirement in the European Union Directive 2010/63/EU “on protection of animals used for scientific purposes.” Training is an essential component to...
Video: The 3T3 Neutral Red Uptake Phototoxicity Test
October 31, 2018This training video explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to video production reasons,...
Non-animal Vaginal Irritation Method Admitted into the US FDA Medical Devices Development Tool (MDDT)
October 18, 2018FDA’s recently launched Predictive Toxicology Roadmap calls for the optimization of non-animal methods for the safety evaluation of drugs, consumer products and medical devices. We have created an Industry Consortium comprised of manufacturers of personal lubricants/vaginal moisturizers and companies interested in the advancement of animal alternatives working collaboratively with stakeholders and the US FDA to develop an in vitro testing approach that could be used in place of the rabbit vaginal irritation (RVI) in pre-market submissions....
The Assessment of Phototoxicity Using the 3T3 Neutral Red Uptake (NRU) Phototoxicity Assay and a Modified Photo-Direct Peptide Reactivity Assay (DPRA)
March 28, 2018Alternative methods, including the validated 3T3 Neutral Red Uptake (NRU) Phototoxicity assay (OECD TG 432) may be used as a pre-clinical test to address phototoxicity. Currently, there are no validated alternative test methods to identify photoallergens; however, there are several validated alternative test methods to address skin sensitization, including the Direct Peptide Reactivity Assay (DPRA) (OECD 442C). To address photoallergy, we utilized the 3T3 Phototoxicity assay in combination with a modified photo-DPRA assay to determine if these assays were able...
Video: The 3T3 Neutral Red Uptake Phototoxicity Test – Spanish
October 6, 2017This new training video explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to video production...
Video: The 3T3 Neutral Red Uptake Phototoxicity Test — Chinese
November 21, 2016This training video with Chinese subtitles explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UVA/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to...
Video: The 3T3 Neutral Red Uptake Phototoxicity Test — Portuguese
November 21, 2016This new training video with Portuguese subtitles explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UV A/dark exposure, should be performed in a biological safety cabinet using aseptic techniques....