Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS | 2018
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August 2018

2018 Lush Prize Shortlist Announced

August 7, 2018
This year saw entries for the first time from Lebanon, Sri Lanka, and Turkey as the reach of the Lush Prize continues to grow.  From the many entrants, reviewers have selected a shortlist of 56 projects and 17 scientists across five award categories who go through to the final judging phase. Winners will be announced in November. Learn More....

Modernization of EPA “6-Pack” of Acute Toxicity Tests Continues

July 27, 2018
The US Environmental Protection Agency (US EPA) continues to drive significant efforts in the United States to modernize the battery of acute toxicity tests classically known as the “6-pack.” Learn More....

Tiered In Vitro Testing Strategy For Assessing The Ocular and Dermal Irritation/Corrosion Potential of Pharmaceutical Compounds

July 23, 2018
Read our latest publication with Bristol-Myers Squibb regarding a tiered testing strategy for occupational hazards of pharmaceutical intermediates now published in the Cutaneous and Ocular Toxicology Journal. Irritation reactions are a frequently reported occupational illness. The potential adverse effects of pharmaceutical compounds (PCs) on employees' eyes and skin can now be assessed using validated in vitro methods. Our overall aim is to reduce animal testing by replacing the historically utilized in vivo test methods with validated in vitro test methods which accurately determine the ocular...

FutureTox IV Registration and Abstract Submission Now Open

July 23, 2018
The Society of Toxicology's FutureTox IV Progress to Maturity: Predictive Developmental and Reproductive Toxicology for Healthy Children is being held in Arlington, VA from November 14 until November 16, 2018. The meeting will focus, among other things, on the impact of environmental factors on developmental health and current translational opportunities and challenges for in vitro data and in silico models in developmental effects assessment and regulatory decision-making for toxicity testing. The Key Note Lectures will be: Assessing Children's Health Trajectories in the Context of Regulatory Decision-Making. Susan...

Laboratory Assistant (Entry Level)

June 28, 2018
We are seeking a part time Laboratory Assistant to work in our Gaithersburg office. This is an exciting opportunity to join and grow with our team to contribute and share in our company vision: A day when methods based on humane, wisely applied science will be used by industry and the regulatory agencies to understand the true safety and efficacy of substances. This position is part time - approximately 20 hours per week. Working hours are flexible; however, need to be...

IIVS e-News – June 2018

June 26, 2018
In this issue, find out the dates for the 2019 Practical Methods Workshop and the PISC award for young scientists, learn about upcoming In Vitro-related meetings and extended deadlines for abstract submission, read recent IIVS publications, and more.  Read issue....

Abstract Deadline Extended for EUSAAT 2018

June 21, 2018
The 21st European Congress on Alternatives to Animal Testing & 18th Annual Congress of EUSAAT (European Society for Alternatives to Animal Testing) will take place in Linz, Austria, 23-26 September.  Submission deadlines for both oral and poster presentations have been extended to July 6. Erin Hill and Rodger Curren from IIVS are both speaking at the event. Learn more about the meeting, including the scientific program, invited speakers, and how to register.  ...

Next-Generation Tobacco and Nicotine Products: Substantiating Harm Reduction and Supporting Tobacco Regulatory Science

June 21, 2018
A framework for the assessment of novel next-generation tobacco and nicotine products with the potential to reduce health risks compared with cigarettes should integrate scientific studies incorporating nonclinical, clinical, and population studies approaches.  These products should have lower emissions and exhibit reduced biological effects compared with those of cigarettes, ideally approaching those of smoking cessation.  The products should also be acceptable cigarette alternatives for current smokers, while not appealing to nonsmokers or former smokers.  Validating harm reduction and promoting regulatory acceptance...

Characterization of a Vitrocell VC1 Using Nicotine Dosimetry: An Essential Component Toward Standardized In Vitro Aerosol Exposure of Tobacco and Next Generation Nicotine Delivery Products

June 21, 2018
The U.S. Food and Drug Administration has regulatory authority over tobacco products, including conventional cigarettes and next generation products (NGPs) such as e-cigarettes and tobacco heating products (THPs).  There is a desire by the industry,  regulator and animal, protection organizations to incorporate non-animal test methods for tobacco product and NGP assessment.  When assessing respiratory effects in vitro, reliable exposure systems that deliver aerosols to cellular/tissue cultures (such as human reconstructed airways or lung slices) at the air–liquid interface are needed.  Using nicotine dosimetry, we report...

Quality Assurance Associate

June 20, 2018
We are seeking a full time Quality Assurance Associate to work in our Gaithersburg office. This is an exciting opportunity to join and grow with our team to contribute and share in our company vision: A day when methods based on humane, wisely applied science will be used by industry and the regulatory agencies to understand the true safety and efficacy of substances. The Quality Assurance Associate is asked to participate in the Quality Assurance monitoring and Good Laboratory Practice auditing...