IIVS, Non Animal Testing, Alternative Test Methods, In Vitro Toxicology | Assays Respiratory Toxicology
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Archive

Next-Generation Tobacco and Nicotine Products: Substantiating Harm Reduction and Supporting Tobacco Regulatory Science

June 21, 2018
A framework for the assessment of novel next-generation tobacco and nicotine products with the potential to reduce health risks compared with cigarettes should integrate scientific studies incorporating nonclinical, clinical, and population studies approaches.  These products should have lower emissions and exhibit reduced biological effects compared with those of cigarettes, ideally approaching those of smoking cessation.  The products should also be acceptable cigarette alternatives for current smokers, while not appealing to nonsmokers or former smokers.  Validating harm reduction and promoting regulatory acceptance...

Characterization of a Vitrocell VC1 Using Nicotine Dosimetry: An Essential Component Toward Standardized In Vitro Aerosol Exposure of Tobacco and Next Generation Nicotine Delivery Products

June 21, 2018
The U.S. Food and Drug Administration has regulatory authority over tobacco products, including conventional cigarettes and next generation products (NGPs) such as e-cigarettes and tobacco heating products (THPs).  There is a desire by the industry,  regulator and animal, protection organizations to incorporate non-animal test methods for tobacco product and NGP assessment.  When assessing respiratory effects in vitro, reliable exposure systems that deliver aerosols to cellular/tissue cultures (such as human reconstructed airways or lung slices) at the air–liquid interface are needed.  Using nicotine dosimetry, we report...

Holger Behrsing, PhD, Participates in Round Table Discussion on Non-Animal Approaches for Inhalation Toxicology

June 14, 2018
Holger Behrsing, PhD, was recently invited to participate in an expert round table discussion convened on the development and implementation of 21st century non-animal approaches to assess the toxicity of inhaled substances.  The discussion included perspectives from government, industry, nonprofit, and academic sectors on the advantages and challenges of using these approaches, ongoing efforts, and steps needed to gain widespread use and acceptance of these approaches. A transcript of the discussion has just been published in Applied In Vitro Toxicology, Vol....

View our Posters from SOT 2018

March 28, 2018
Thank you to all who visited our booth at the 2018 SOT meeting.  Our scientists presented several posters at the meeting. If you did not have an opportunity to view our posters, or would like to view them again, we now have them available here to view online. ...

IIVS Posters at SOT 2018

March 28, 2018
 2018 Society of Toxicology (SOT) Annual Meeting March 11-15, 2018 San Antonio, TX Thank you to all who visited us at the 2018 SOT meeting. View our posters presented at the meeting.  Respiratory Toxicology Nicotine Characterization of an In Vitro Inhalation Exposure System Using Conventional and Next-Generation Tobacco Products: A US/UK Inter-Laboratory Comparison Oral Irritation Assessment of Electronic Liquids Using an In Vitro Oral Testing Model Use of Ex Vivo Precision-Cut Lung Slices as a Screening Tool for Potential Respiratory Toxicity of E-Liquids Human In...

IIVS at SOT 2018

February 8, 2018
IIVS will have several events and posters at the upcoming SOT meeting, March 11-15, in San Antonio, TX.  The events and three of our five posters focus on our respiratory toxicology program in support of our new laboratory that opened in 2017.  Other posters examine topics in phototoxicity.  Be sure to visit our booth at the meeting - Booth #533.   View more details on our events and posters at SOT....

In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products: Workshop Proceedings, Conclusions and Paths Forward for In Vitro Model Use

August 17, 2017
In 2009, the passing of the Family Smoking Prevention and Tobacco Control Act facilitated the establishment of the FDA Center for Tobacco Products (CTP), and gave it regulatory authority over the marketing, manufacture and distribution of tobacco products, including those termed ‘modified risk’. On April 4-6, 2016, IIVS convened a workshop conference entitled, In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products, to bring together stakeholders representing regulatory agencies, academia and industry to address the research priorities...

Awards of VITROCELL In Vitro Inhalation Exposure Systems

June 30, 2017
The PETA International Science Consortium (PISC) awarded four VITROCELL in vitro exposure systems to researchers from institutions in the UK, US, and Belgium who are leading the development of non-animal methods to test the toxicity of airborne substances. IIVS is grateful to PISC for donating the VITROCELL System for use in its new respiratory toxicology laboratory. The new lab provides  non-animal testing services for evaluating potential respiratory hazards associated with novel ingredients and chemistries used in fragrances, personal care products, household and institutional cleaning...