Archive

Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology

October 18, 2016
This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides... 3T3 Neutral Red Uptake | Acute Respiratory Toxicity | Assessing Corneal Recovery | BCOP | Bronchial/Tracheal | CAMVA | Chronic Respiratory Toxicity | Ciliary Beat Frequency | Corneal Recovery Modeling | Corrositex

Ocular Irritection (OECD 496)

August 24, 2016
The Ocular Irritection Assay is an in chemico eye irritation assay that detects, ranks, and predicts the corneal irritation potential of a test material. The assay assesses changes to the reagent solution (containing proteins, glycoproteins, lipids), which mimics the denaturation and disruption that occurs in corneal proteins in vivo.The test article is applied to a membrane disc that controls the delivery to the reagent solution. The changes in the protein structure are measured by optical density readings in the reagent... Assessing Corneal Recovery | BCOP | CAMVA | Corneal Recovery Modeling | Eye Irritation Test | NociOcular Eye Sting | Ocular Screening | Short Time Exposure

Short Time Exposure (STE, OECD 491)

August 24, 2016
The Short Time Exposure (STE) assay, developed by Kao Corporation (Japan), is an in vitro assay used to assess acute eye irritation potential as an alternative to the traditional in vivo Draize test. The test method evaluates the cytotoxicity induced by a series of test chemical dilutions in a monolayer of rabbit corneal fibroblasts (Statens Seruminstitut Rabbit Cornea – SIRC) after a single five-minute exposure. Two prediction models were initially developed for the STE assay — one categorizes the test material as... BCOP | CAMVA | Corneal Recovery Modeling | Eye Irritation Test | Eye Irritation Time-to-Toxicity | NociOcular Eye Sting | Ocular Irritection | Short Time Exposure | Agro/Petrochemical | Cosmetic & Personal Care

Eye Irritation Test using Reconstructed Human Corneal Epithelium (RhCE) Models (EIT, OECD 492)

August 24, 2016
The Eye Irritation Test (EIT) is an OECD-approved in vitro non-animal test method for identifying chemicals and mixtures that may be irritating to the corneal epithelium. The test method utilizes an in vitro reconstructed human corneal epithelium (RhCE) model (EpiOcular™, MatTek Corp. or HCE, SkinEthic™), in an acute exposure assay to support international regulatory labeling requirements, according to the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). The Eye Irritation Test can be used to support... Assessing Corneal Recovery | BCOP | Corneal Recovery Modeling | Ocular Screening | Cleaning Products | Cosmetic & Personal Care | Fragrance & Flavors | Household & Consumer Products | Occupational Safety & Industrial Hygiene | Specialty Chemical

Webinar: Serious Eye Damage and Eye Irritation

Investigations on Reducing Ocular Irritation Associated with Harsh Ingredients by Altering Physicochemical Properties of the Formulation

March 25, 2014
Source: SOT 2014... BCOP | Corneal Recovery Modeling | Household & Consumer Products

CHOOSING THE APPROPRIATE SOLVENT FOR SOLID MATERIALS TESTED IN THE BOVINE CORNEAL OPACITY AND PERMEABILITY (BCOP) IN VITRO ASSAY

March 12, 2013
Source: Presented at the 2013 Society of Toxicology Annual Meeting... BCOP | Corneal Recovery Modeling | Specialty Chemical