Author: Jane Ryan

Webinar: Revisiting Skin Irritation Testing Strategies Applying Non animal Test Methods

Cytokine induction in the 3D EpiDerm™ skin model used as an in vitro preclinical screening tool for formulations with anti-inflammatory action

US Institute Trains Chinese Scientists from Zhejiang FDA in Non-Animal Test Methods

August 31, 2015
GAITHERSBURG, Md.- In an effort to reduce the number of animals used in the registration and testing of cosmetics in China, US non-profit laboratory, the Institute for In Vitro Sciences (IIVS), provided in-depth training for two scientists from the Zhejiang Food and Drug Administration’s Institute for Food and Drug Control (ZJFDA IFDC). The course focused on laboratory techniques using more predictive and human relevant test methods such as reconstructed human skin and eye models. The training was designed to assist... China | Education & Outreach

Workshop Report: Assessment of In Vitro COPD Models for Tobacco Regulatory Science

July 10, 2015
Source: IIVS December 2014 Workshop See also In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products from our April 2016 workshop.... Acute Respiratory Toxicity | Bronchial/Tracheal | Chronic Respiratory Toxicity | Goblet Cell Hyperplasia | Pulmonary Models | Respiratory Toxicology | Tobacco

Industry and Regulatory Collaboration Pays Off for Animals

June 5, 2015
Gaithersburg, MD – The Environmental Protection Agency has updated a policy which will result in fewer products required to be tested in the eyes of rabbits. The policy is the outcome of a multi-year project between industry, the EPA and the non-profit testing laboratory, the Institute for In Vitro Sciences (IIVS). Coordinated by The Accord Group, the project successfully identified three non-animal tests which can be used to in place of the rabbit test to determine the eye irritation potential... Working with Regulators

Webinar: In Vitro 3T3 Phototoxicity Assay Practical Experiences Assay Optimization and Challenges

Protocol Considerations for Testing Surfactants and Surfactant-based Formulations in the Bovine Corneal Opacity and Permeability Assay

March 23, 2015
The Bovine Corneal Opacity and Permeability (BCOP) assay is an ex vivo test for predicting ocular irritation. For regulatory classification, OECD Test Guideline (TG) 437 specifies that liquid and solid surfactants may be tested as 10% aqueous dilutions for 10 minutes, although alternate dilutions and exposure times may be conducted with scientific rationale. Without question, surfactant solids should not be tested using the solid chemical protocol, since overexposure conditions are likely. In the absence of clear guidance from these regulatory... BCOP | Cosmetic & Personal Care | Household & Consumer Products | Specialty Chemical