Archive
Webinar: Skin Tone Modulation: In Vitro Pre-clinical and Clinical Efficacy Testing Strategies and Innovative Solutions in Cosmetics
July 13, 2017Addressing uneven skin tone often associated with photo-aging is a key area of interest in the cosmetic industry. The design of novel, safe, and efficacious actives and ingredients capable of inducing subtle changes in skin tone can be accomplished using modern, relevant and reliable pre-clinical testing strategies prior to clinical assessment. During this one-hour webinar, IIVS Study Director, Dr. Gertrude-Emilia Costin and Dr. Manpreet Randhawa, Principal Scientist at Johnson & Johnson, discuss optimized in vitro testing platforms using pigmented tissue models...
IIVS Recipient of Device that Mimics Human Exposure to Aerosols
July 10, 2017PETA International Science Consortium Donates VITROCELL® In Vitro Inhalation Exposure System GAITHERSBURG, MD – July 10, 2017 – The Institute for In Vitro Sciences (IIVS), a leader in non-animal test methods, is the recipient of a VITROCELL® inhalation exposure system thanks to a generous donation by the PETA International Science Consortium. The device, which is designed to replace animals in inhalation testing, can be used to expose human lung cells to airborne test materials in an environment that mimics the human lung. IIVS will use...
IIVS Works with MAC Cosmetics and Others to Reduce and Eliminate Animal Testing
July 10, 2017Eliminating animal testing is core to our mission. With the support of contributors like MAC Cosmetics, we are making real progress. Read this article in Teen Vogue that talks about our work and how companies like MAC Cosmetics are making a difference. Read article....
View Our Webinar on Skin Tone Modulation
June 30, 2017View the recording and slides from our webinar on skin tone modulation that was held on Thurs., June 29. The one-hour webinar features IIVS study director, Dr. Gertrude-Emilia Costin, and Johnson & Johnson principal scientist, Dr. Manpreet Randhawa as they discuss optimized in vitro testing platforms using pigmented tissue models that assess the capacity of ingredients and formulations that impact skin tone. ...
Navigating the Claim Substantiation Maze in Cosmetics Industry
June 15, 2017Read this article by IIVS study director Dr. Gertrude-Emilia Costin and biologist Asha Shravanthi Pidathala in the June 2017 issue of Eurocosmetics. The article examines modern, relevant, and reliable in vitro testing strategies using pigmented tissue models that assess the capacity of ingredients and formulations that impact skin tone. ...
Toxicity Testing: Read Between the Lines
April 13, 2017Skin toxicity testing was the focus of a full-day seminar held during In-Cosmetics 2017. Attendees learned about everything from skin absorption and metabolism, to cytotoxicity, phototoxicity and sensitization. IIVS Study Director, Dr. Tinashe Ruwona, presented on integrated testing strategies to evaluate the skin sensitization potential of cosmetics. However, the biggest take-away from the seminar seemed to rest on how well the results of a study are understood. Read the full article. ...
IIVS Attends In-Cosmetics Global
April 4, 2017IIVS President, Erin Hill, and Study Director, Tinashe Ruwona are attending the In-Cosmetics Global meeting, April 4-6, in London. Dr. Ruwona, who leads our skin sensitization screening program, presented during the Skin Toxicology Workshop. His presentation, "Integrated Testing Strategies for Assessing the Skin Sensitization Potential of Cosmetics", Dr. Ruwona explores the various test methods and how best to combine them to ensure consumer safety. Read more....
Addressing the Assignment of US EPA Hazard Categories for Dermal Safety by a Revised Prediction Model of the Validated In Vitro Skin Irritation Test (OECD TG 439)
March 30, 2017One of the current goals of the United States Environmental Protection Agency Office of Pesticide Programs (US EPA OPP) is to replace by non-animal testing methods as many of the endpoints of the battery of acute toxicity tests known as the “6-pack” as possible. One of the “6-pack” tests is the Draize rabbit test for dermal irritation. We investigated whether the validated in vitro Skin Irritation Test (SIT, OECD TG 439) can be used to determine US EPA OPP dermal...
In Vitro Assessment of Skin Irritation Potential of Surfactant-based Formulations by Using a 3-D Skin Reconstructed Tissue Model and Cytokine Response
January 24, 2017The personal care industry is focused on developing safe, more efficacious, and increasingly milder products, that are routinely undergoing preclinical and clinical testing before becoming available for consumer use on skin. In vitro systems based on skin reconstructed equivalents are now established for the preclinical assessment of product irritation potential and as alternative testing methods to the classic Draize rabbit skin irritation test. We have used the 3-D EpiDerm™ model system to evaluate tissue viability and primary cytokine interleukin-1α release...
Video: The 3T3 Neutral Red Uptake Phototoxicity Test — Chinese
November 21, 2016This training video with Chinese subtitles explores a cell-based method for assessing Phototoxicity — or the potential for chemicals to cause damage after being exposed to light. The method is used widely around the world by many industries, including the cosmetics and pharmaceutical sectors. Disclaimer: Please note that the procedures shown in this video were for demonstration purposes only and that all assay procedures, except the UVA/dark exposure, should be performed in a biological safety cabinet using aseptic techniques. Due to...