Uncategorized
Cytokine induction in the 3D EpiDerm™ skin model used as an in vitro preclinical screening tool for formulations with anti-inflammatory action
October 1, 2015Source: ASCCT 2015...
US Institute Trains Chinese Scientists from Zhejiang FDA in Non-Animal Test Methods
August 31, 2015GAITHERSBURG, Md.- In an effort to reduce the number of animals used in the registration and testing of cosmetics in China, US non-profit laboratory, the Institute for In Vitro Sciences (IIVS), provided in-depth training for two scientists from the Zhejiang Food and Drug Administration’s Institute for Food and Drug Control (ZJFDA IFDC). The course focused on laboratory techniques using more predictive and human relevant test methods such as reconstructed human skin and eye models. The training was designed to assist...
Workshop Report: Assessment of In Vitro COPD Models for Tobacco Regulatory Science
July 10, 2015Source: IIVS December 2014 Workshop See also In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products from our April 2016 workshop....
Industry and Regulatory Collaboration Pays Off for Animals
June 5, 2015Gaithersburg, MD – The Environmental Protection Agency has updated a policy which will result in fewer products required to be tested in the eyes of rabbits. The policy is the outcome of a multi-year project between industry, the EPA and the non-profit testing laboratory, the Institute for In Vitro Sciences (IIVS). Coordinated by The Accord Group, the project successfully identified three non-animal tests which can be used to in place of the rabbit test to determine the eye irritation potential...
Webinar: In Vitro 3T3 Phototoxicity Assay Practical Experiences Assay Optimization and Challenges
April 9, 2015...
Protocol Considerations for Testing Surfactants and Surfactant-based Formulations in the Bovine Corneal Opacity and Permeability Assay
March 23, 2015The Bovine Corneal Opacity and Permeability (BCOP) assay is an ex vivo test for predicting ocular irritation. For regulatory classification, OECD Test Guideline (TG) 437 specifies that liquid and solid surfactants may be tested as 10% aqueous dilutions for 10 minutes, although alternate dilutions and exposure times may be conducted with scientific rationale. Without question, surfactant solids should not be tested using the solid chemical protocol, since overexposure conditions are likely. In the absence of clear guidance from these regulatory...
A TIERED IN VITRO IRRITATION/CORROSION TESTING STRATEGY FOR GHS CLASSIFICATION OF PHARMACEUTICAL COMPOUNDS
March 23, 2015Source: 2015 Society of Toxicology Meeting...
Evaluation of TRPV1 Activity to Assess the Eye Stinging Potential of Cosmetic Formulations
March 23, 2015Source: 2015 Society of Toxicology Meeting...
Using the Novel NociOcular Assay to Predict the Eye Sting Potential of Shampoos and Sunscreen Products
March 23, 2015Source: 2015 Society of Toxicology Meeting...
Replacing Animals for Skin Sensitization Testing Gains Momentum as OECD Publishes Test Guidelines for Non-Animal Based Methods
February 11, 2015GAITHERSBURG, MD - Determination of skin sensitization potential is a critical toxicological endpoint in the safety assessment of new chemicals. Although the Guinea Pig Maximization Test (GPMT) and in vivo Local Lymph Node assay (LLNA) have traditionally been used to assess skin sensitization, recent activity has focused on the development of novel non-animal assays for the endpoint. As a culmination of these efforts, the Organization for Economic Cooperation and Development (OECD) published the following test guidelines for non-animal skin sensitization...