This 13- minute video demonstrates how to perform the BCOP assay according to the Test Guidelines set forth for the assay by the Organization for Economic Co-operation and Development (OECD TG 437). The video focuses on steps that are critical to the success of the assay such as handling of the isolated cornea and removal of the test material from the cornea at the conclusion of the exposure time...
BCOP | Agro/Petrochemical | Cosmetic & Personal Care | Household & Consumer Products | Medical Devices | Occupational Safety & Industrial Hygiene | Pharmaceutical | Specialty ChemicalThis 13- minute video demonstrates how to perform the BCOP assay according to the Test Guidelines set forth for the assay by the Organization for Economic Co-operation and Development (OECD TG 437). The video focuses on steps that are critical to the success of the assay such as handling of the isolated cornea and removal of the test material from the cornea at the conclusion of the exposure time...
BCOP | Agro/Petrochemical | Cosmetic & Personal Care | Household & Consumer Products | Medical Devices | Occupational Safety & Industrial Hygiene | Pharmaceutical | Specialty ChemicalThis 13- minute video demonstrates how to perform the BCOP assay according to the Test Guidelines set forth for the assay by the Organization for Economic Co-operation and Development (OECD TG 437). The video focuses on steps that are critical to the success of the assay such as handling of the isolated cornea and removal of the test material from the cornea at the conclusion of the exposure time...
BCOP | Agro/Petrochemical | Cosmetic & Personal Care | Household & Consumer Products | Medical Devices | Occupational Safety & Industrial Hygiene | Pharmaceutical | Specialty ChemicalSource: ASCCT 2015
Inflammatory Cytokine Expression | Irritation Screening | Skin Irritation Test | Vaginal Irritation | Cosmetic & Personal Care | Medical Devices | Specialty ChemicalSource: IIVS December 2014 Workshop See also In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products from our April 2016 workshop.
Acute Respiratory Toxicity | Bronchial/Tracheal | Chronic Respiratory Toxicity | Goblet Cell Hyperplasia | Pulmonary Models | Respiratory Toxicology | TobaccoThe Bovine Corneal Opacity and Permeability (BCOP) assay is an ex vivo test for predicting ocular irritation. For regulatory classification, OECD Test Guideline (TG) 437 specifies that liquid and solid surfactants may be tested as 10% aqueous dilutions for 10 minutes, although alternate dilutions and exposure times may be conducted with scientific rationale. Without question, surfactant solids should not be tested using the solid chemical protocol, since overexposure conditions are likely. In the absence of clear guidance from these regulatory documents, we present on the testing of a few common surfactant ingredients (sodium lauryl sulfate, Triton X-100, and benzalkonium chloride), and surfactant-based liquid and solid formulations in BCOP using standard and modified dilutions and exposures to evaluate the impact of these variables.
BCOP | Cosmetic & Personal Care | Household & Consumer Products | Specialty ChemicalSource: 2015 Society of Toxicology Meeting
BCOP | Corrositex | Irritation Screening | Skin Irritation Corrosion Screening | Skin Irritation Test | Pharmaceutical | Assay Validation