Archive
Defined Approaches for Skin Sensitization (Based on OECD TG 497)
June 27, 2021Determination of skin sensitization potential is a critical endpoint in the safety assessment of raw materials, chemicals, mixtures and formulations. Although the Guinea Pig Maximization Test (GPMT) and Local Lymph node assay (LLNA) have historically been used to address this adverse effect, in silico and in vitro assays have been developed and validated in order to replace these resource-intensive animal tests. In 2012, the Organization for Economic Co-operation and Development (OECD) published the Adverse Outcome Pathway (AOP) describing the sequence of molecular and cellular events...
Modernization of EPA “6-Pack” of Acute Toxicity Tests Continues
July 27, 2018The US Environmental Protection Agency (US EPA) continues to drive significant efforts in the United States to modernize the battery of acute toxicity tests classically known as the “6-pack.” Learn More....
Defined Approaches for EPA Testing
July 26, 2018The US Environmental Protection Agency (US EPA) continues to drive significant efforts in the United States to modernize the battery of acute toxicity tests classically known as the “6-pack.” Known for many years as an “all in vivo” testing strategy for products registered under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), the 6-pack was revised in 2015 to include non-animal (in vitro/ex vivo) test methods for classification and labeling for Eye Irritation, both for commonly used household cleaning products...
Webinar: How GLPs Enhance the Quality of Regulated and Non-Regulated Toxicology
October 18, 2016This one-hour webinar, led by IIVS Director of Quality and Compliance, introduces some of the concepts of Good Laboratory Practices (GLPs) designed to promote study and data integrity within an in vitro toxicology framework. Applying these concepts within your own laboratory should aid in production of robust, repeatable studies. View Slides...
Integrated Testing Strategies for Skin Sensitization
August 24, 2016Determination of skin sensitization potential is a critical endpoint in the safety assessment of raw materials, chemicals, mixtures and formulations. Although the Guinea Pig Maximization Test (GPMT) and Local Lymph node assay (LLNA) have historically been used to address this adverse effect, in vitro assays have been developed and validated in order to replace these resource-intensive animal tests. Skin sensitization is the result of a series of biochemical "Key Events" (KEs) that involve covalent binding of (generally electrophilic) compounds to cellular...
Webinar: Regulatory Initiatives for New Approaches to Traditional Toxicity Testing
July 1, 2016This one-hour webinar features presentations by Dr. Jennifer McLain, Deputy Director, Office of Pesticide Programs, Antimicrobial Division and IIVS CEO Dr. Rodger Curren. Dr. McLain discusses the EPA OPP's plans to reduce the use of animal testing in acute toxicity testing and provides suggestions on how stakeholders and EPA can cooperate to advance animal reduction goals. Dr. Curren then talks about IIVS' activities in developing the current non-animal strategy for eye irritation, and recent investigations into in vitro methods to...
Mimicking Metabolism Using Human Microsomes in Two In Vitro Assays in Order to Predict the Sensitization Potential of Pro-haptens
April 1, 2016Source: Pan-American Conference on Alternatives...
Momentum Grows for Modernizing the US EPA “Six-pack” Battery of Acute Toxicity Tests
January 13, 2016In the current global regulatory climate favorable for further advancement of in vitro test methods, the US Environmental Protection Agency (US EPA) is driving significant efforts in the United States. The latest endeavor targets the modernization of the battery of acute toxicity tests classically known as the “six-pack” (Fig. 1a). Known for many years as an “all in vivo” testing strategy for products registered under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), the six-pack has recently been revised to include...